WebBackground A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein, WebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between …
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WebNov 30, 2024 · Objective: To review glucose-lowering efficacy and changes in renal function associated with sodium-glucose co-transporter 2 (SGLT2) inhibitors among patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM). WebMay 18, 2024 · The high incidence of cisplatin-induced nephrotoxicity in elderly patients may be associated with renal hypoperfusion; increased comorbidities, such as chronic kidney disease (CKD), cardiovascular disease, and diabetes mellitus; increased use of combined drugs [especially non-steroidal anti-inflammatory drugs, angiotensin …
WebElectrolyte disturbance: Cisplatin can cause hypomagnesaemia, hypokalaemia and hypocalcaemia. The hypocalcaemia seems to occur in those with low serum magnesium secondary to cisplatin, so it is not … WebDec 3, 2024 · Cisplatin-based chemotherapy (CBCT) is part of standard treatment of several cancers. In testicular cancer (TC) survivors, an increased risk of developing metabolic syndrome (MetS) is observed. In this epigenome-wide association study, we investigated if CBCT relates to epigenetic changes (DNA methylation) and if epigenetic …
WebAgeing kidney; cardiovascular disease; cisplatin nephrotoxicity; diabetes mellitus; lung cancer; High-dose cisplatin (Cp)-based combination chemotherapy regimens are used as front-line treatments of nonsmall cell and small cell lung cancer 1.The therapeutic effects of Cp are significantly improved by dose escalation. WebApr 5, 2024 · Poorly controlled diabetes (fasting blood glucose [FBG] > 10 mmol/L); ... Known hypersensitivity to active ingredients or excipients of the study drug, such as envafolimab and cisplatin; Subjects who have concomitant diseases that, in the investigator 's judgment, would seriously jeopardize the subject' s safety or affect the completion of …
WebFeb 1, 2003 · Cisplatin, a heavy metal coordination compound that induces apoptosis of cancer cells, is widely used in a variety of cancers. Cisplatin treatment induced transient …
WebSep 1, 2024 · Cisplatin, the active ingredient in Cisplatin for injection, USP, is a yellow to orange crystalline powder with the molecular formulaCl 2 H 6 N 2 Pt and a molecular weight of 300.05. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. dell thermostatWebDec 16, 2024 · Cisplatin (CDDP; cis-dichlorodiammine platinum [II]) is a non-specific drug of the cell cycle with strong cytotoxicity and broad-spectrum antitumor effects; it is widely used in urogenital system tumors, malignant lymphoma, breast cancer, head and neck cancer, non-small cell lung cancer, etc. ( 1 – 3) Cisplatin-induced nephrotoxicity is … festival psychedelicWebNov 26, 2013 · The short-term effects of not treating diabetes include frequent urination and severe thirst, fatigue, and recurrent infections. The long-term effects include loss of vision, kidney problems, heart disease, and nerve damage. “Cancer is also an under-appreciated long-term risk resulting from obesity, prediabetes, and type 2 diabetes,” he adds. festival resort vacation homesWebApr 1, 2013 · Pathophysiology of Diabetes Insipidus (DI) DI is a clinical syndrome characterized by polyuria (due to a defect in the urinary concentrating mechanism) and compensatory polydipsia. In the general population, the prevalence of DI is approximately one per 25,000–30,000 ( 7 – 9 ). festival rave wearCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side effects include bone marrow suppression, hearing problems, incl… festival rebirthfestival rhoonWebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin … dell thin and light laptop