Cisplatin pubmed

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August undefined, 2024

WebDec 1, 2024 · Methods. In this open-label, randomized, phase III study, newly diagnosed patients with advanced NSCLC were initially randomized (R1, 1:1) to receive first-line treatment with cisplatin 75 mg/m 2 plus docetaxel 75 mg/m 2 (DC75) or 60 mg/m 2 (DC60) for up to 4 cycles. Patients without progression were further randomized (R2, 1:2) to best … WebCisplatin is one of the most widely used antineoplastic agents in the treatment of solid tumour and haematological malignancies, including cancers of the testes, ovary, bladder, head and neck, oesophagus, stomach and lung, as well as lymphoma and osteosarcoma.

Efficacy and tolerability of concurrent weekly low dose ... - PubMed

WebCisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer, etc. WebJun 21, 2024 · This trial compared cisplatin with cisplatin plus delayed administration of … duster rally dash

Population pharmacokinetics of cisplatin in small cell lung …

WebWe aimed to evaluate cisplatin pharmacokinetics (PK) and the exposure to unbound … WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine monophosphate … WebJan 28, 2024 · In this study, we sought to provide a comprehensive review of the current state of the science highlighting the use of cisplatin in cancer therapy, with a special emphasis on its molecular mechanisms of action, and treatment modalities including the combination therapy with natural products. cryptoknight1906 on uphold wallet

In vitro evaluation of sustained drug release from biodegradable ...

Cisplatin pubmed

Gemcitabine and cisplatin plus durvalumab with or without

WebJun 1, 2024 · After completion of gemcitabine and cisplatin, 1500 mg of durvalumab or … WebIntroduction: Cisplatin, a platinum-based antineoplastic agent, is the cornerstone for the …

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WebAug 8, 2010 · Cisplatin is one of the most effective anticancer agents widely used in the … WebFor some tumors, cisplatin appears to be superior to carboplatin in terms of therapeutic effectiveness (germ cell tumors, bladder cancer, head and neck cancer), while for others, effectiveness is comparable (lung cancer, ovarian cancer). Toxicity profiles are distinctly different for the two analogu …

WebJul 1, 2024 · Background/aim: Cisplatin combined with pemetrexed disodium heptahydrate (pemetrexed) is considered the standard treatment for patients with advanced, non-squamous, non-small-cell lung cancer. However, its growth-inhibitory effects on KRAS-dependent lung cancer as monotherapy and combination therapy are not well understood. WebSep 3, 1991 · After a preliminary dose-finding study involving 12 patients with advanced or locally recurrent head and neck cancer, 27 patients were treated on a phase II protocol, using fluorouracil 350 mg/m2/d by continuous intravenous (IV) infusion over 5 days, followed on the sixth day by a 2-hour IV infusion …

WebOct 20, 2003 · Abstract. Cisplatin is one of the most potent antitumor agents known, … WebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and …

WebCisplatin and MD-805 were loaded in the films by casting the polymer solution containing the drugs. Fractions of the drugs released from the PLA-CL films were governed by the initial loading, the film thickness, and the polymer molecular weight. The drug release profiles obeyed the classical Fickian diffusion equation at least in the early ...

WebIntroduction: The aim of this multicenter phase II trial was to evaluate the combination of oral vinorelbine and cisplatin with radiotherapy (RT) after cisplatin-docetaxel induction chemotherapy (CT) in patients with locally advanced non-small cell lung cancer (NSCLC). Patients and methods: Patients with previously untreated, inoperable, histologically or … cryptokord.networkWebCisplatin is a highly effective antitumor drug generally used in the treatment of solid … duster oroch outsider plus 2.0WebThe platinum analogues, cisplatin and carboplatin, are among the most widely used chemotherapeutic agents in oncology. Both agents have a broad spectrum of clinical activity in numerous malignancies including gynaecological cancers, germ cell tumours, head and neck cancer, thoracic cancers and bladd … cryptoknight heavy cpu hashrateWebCisplatin / metabolism Cisplatin / pharmacology* Cisplatin / therapeutic use Combined … duster projector headlightsWebWe demonstrate that cisplatin-induced transition from epithelial to mesenchymal … duster rallyWebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an … cryptoknowmics.comWebKidney injury molecule-1 (KIM-1) is a novel biomarker promising the diagnosis of AKI in early stages. We studied whether urinary and serum KIM-1 (KIM-1 U and KIM-1 S ) concentrations were useful in predicting cisplatin-induced AKI in early stages. Methods: We prospectively analysed 22 patients on cisplatin treatment. cryptokoxp.com