Lactate metabolism in lung tumors
WebTargeted therapy is an efficient treatment for patients with epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC). Therapeutic resistance invariably occurs in NSCLC patients. Many studies have focused on drug resistance mechanisms, but only a few have addressed the metabolic flexibility in drug-resistant NSCLC. In the present … WebAbstract. Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate contributes to energy metabolism in living tumors. We previously reported …
Lactate metabolism in lung tumors
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WebNov 21, 2024 · Based on our short- and long-term analyses of six datasets of lung adenocarcinoma immunotherapies downloaded from the GEO database, we found that lactate metabolism may play a potential role in promoting the therapeutic effect of anti-PD-1 monoclonal antibodies. WebFeb 1, 2024 · The presence of lactate in human tumours has been long neglected, confined to the role of a waste product derived from glycolysis and as a biomarker of malignancy. More recently, lactate has been rediscovered as signalling molecule that plays important roles in the regulation of the metabolic pathways, the immune response, and cell-to-cell ...
WebApr 12, 2024 · Metabolic reprogramming is considered one of the main driving forces for tumor progression, providing energy and substrates of biosynthesis to support rapid neoplastic proliferation. Particularly, the tumor suppressor protein p53 was shown to revert the Warburg effect and play complex roles in regulating glucose metabolism. Jumonji C … WebAug 23, 2024 · Targeting lactate metabolism and transport is a promising approach for cancer therapeutics. The presence of lactate in human tumours has been long neglected, confined to the role of a waste product …
WebVolume 171, Issue 2, 5 October 2024, Pages 358-371.e9. Article. Lactate Metabolism in Human Lung Tumors WebIt is unknown whether lactate contributes to energy metabolism in living tumors. We previously reported that human non-small-cell lung cancers (NSCLCs) oxidize glucose in the tricarboxylic acid (TCA) cycle. Here, we show that lactate …
WebMar 22, 2024 · Background: It has been suggested that lactate metabolism (LM) is crucial for the development of cancer. Using integrated single-cell RNA sequencing (scRNA-seq) analysis, we built predictive models based on LM-related genes (LMRGs) to propose novel targets for the treatment of LUAD patients.
WebApr 14, 2024 · Background RNA-binding motif protein 14 (RBM14) is upregulated in a variety of tumors. However, the expression and biological role of RBM14 in lung cancer remain unclear. Methods Chromatin immunoprecipitation and PCR were carried out to measure the levels of sedimentary YY1, EP300, H3K9ac, and H3K27ac in the RBM14 promoter. Co … adonis medical billingadonis lattimore vWebOct 5, 2024 · It is unknown whether lactate contributes to energy metabolism in living tumors. We previously reported that human non-small-cell lung cancers (NSCLCs) oxidize … adonism religionWebNov 21, 2024 · Based on our short- and long-term analyses of six datasets of lung adenocarcinoma immunotherapies downloaded from the GEO database, we found that … adonis full movieWebOct 20, 2016 · The new study shows that mitochondria can contain one of the enzymes associated with lactate metabolism, Dr. DeBerardinis continued. In his study of lung tumors, Dr. DeBerardinis had assumed that … jsr hagシリーズWebLactate has been observed to fuel TCA cycle and is associated with cancer progression in human lung cancer, the leading cause of cancer deaths worldwide, but the effect of lactate on lung cancer metabolism is rarely reported. adonis dallasWebLactate Metabolism in Human Lung Tumors.. Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate contributes to energy metabolism in living … adonis strata